Useful Information 
Locations
Resources
Course Material
There are a number of items available
for BIOSCI 353 in the Short Loans Collection which is
located on level 1 of the Kate Edger Information Commons.
To see the full list of items, go to the
Course Materials search
page on the library page, scroll down the alphabetical list of courses to find
the entry for BIOSC353 and click on the Search tab.
I
tems are in alphabetical order by title and may include books and
individual articles.
Reading List
Course readings may only be used for the University's educational purposes. You may print a copy for your own use, but you may not make a further copy for any other purpose. You may not copy or distribute any part of the reading to any other person. Failure to comply with these terms may expose you to legal action for copyright infringement and/or disciplinary action by the University.
Readings available for the following lecturers/lecture blocks:
To access these electronic resources refer to the Accessing Electronic Resources : On Campus | From Home instructions.
BIOSCI 353 Lecture Readings by Lecture/Lecturer
Dr Christina Buchanan
- Draznin, B., & LeRoith, D. (1994). Molecular biology of diabetes. Totowa, N.J: Humana Press.
- Wrenshall, G.A., Hetenyi, G., & Feasbyet, W.R. (1962). The story of insulin : forty years of success against diabetes. Toronto: M. Reinhardt.
- Tirone, T.A., & Brunicardi, F.C. (2001). Overview of Glucose Regulation. World Journal of Surgery, 25(4), 461-467
- Renstrom E, Sebastian, B., Thevenod, F., & Rorsman. P. (2002). Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action. Diabetes, 51(suppl.1), S33-S36.
- Kieffer, T.J., & Habener, J.F. (1999). The Glucagon-Like Peptides. Endocrine Reviews, 20(6), 876-913.
- Kennedy, R.T., Kauri, L.M., Dahlgren, D.M., & Jung,S. (2002). Metabolic oscillations in beta-cells. Diabetes, 52(suppl 1), S152-S161.
- Nesher, R., & Cerasi, E. (2002). Modeling phasic insulin relseas; Immediate and time-dependant effects of glucose. Diabetes, 51(suppl 1), S53-S59.
- Henquin, J., Ishiyama, N., Nenquin, M., Ravier, M.A. (2002). Signals and pools underlying biphasic insulin sceretion. Diabetes, 51(suppl 1), S60-S67.
- Whitehead, J.P., Clark, S.F., Ursø, B., & James, D.E. (2000). Signalling through the insulin receptor. Current Opinion in Cell Biology, 12, 222-228
- Sesti, G., Federici, M., Hribal, M.L., Lauro, D., Sbraccia, P., & Lauro, R. (2001). Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. The FASEB Journal, 15(12), 2099-2111.
- Cohen P. (1999). The Croonian Lecture 1998: Identification of a protein kinase cascade of major importance in insulin signal transduction. Philosophical transactions of the Royal Society of London Series B, Biological Sciences, 354(1382), 485-495.
Dr Debbie Hay
Topic 1: Introduction to G protein-coupled receptor (GPCR)) signalling
- Berg et al (6th Edition), Biochemistry, chapter 14
- Pierce, K.L,. Premont, R.T., and Lefkowitz, R.J. (2002). Seven Transmembrane Receptors. Nature Reviews Molecular Cell Biology, 3, 639-650. doi:10.1038/nrm908
- Lagerström M.C., and Schiöth, H.B. (2008). Structural diversity of G protein-coupled receptors and significance for drug discovery, Nature Reviews Drug Discovery, 7, 339-357. doi:10.1038/nrd2518
Topic 2: Biosynthesis and regulation of GPCR function by post-translational modifications, sequence variation and splicing
- Achour, L., Labbé-Jullié, C., Scott, M.G.H., Marullo, S. (2008). An escort for GPCRs: implications for regulation of receptor density and the cell surface. Trends in Pharmacological Sciences, 29, 528-535. doi:10.1016/j.tips.2008.07.009
- Tobin, A.B. (2008). G-protein-coupled receptor phosphorylation: where, when and by whom. British Journal of Pharmacology, 153, S167-176. doi:10.1038/sj.bjp.0707662
- Tobin, A.B., Butcher, A.J. and Kong, K.C. (2008), Location, location, location….site-specific GPCR phosphorylation offers a mechanisms for cell-type-specific signalling. Trends in Pharmacological Sciences, 29, 413-420. doi:10.1016/j.tips.2008.05.006
- Marcovic, D. and Grammatopoulos, D.K. (2009). Focus on the splicing of Secretin GPCRs transmembrane-domain 7. Trends in Biochemical Sciences, 34, 443-452. doi:10.1016/j.tibs.2009.06.002
- Marcovic, D., and Challis, R.A.J. (2009). Alternative splicing of G protein-coupled receptors: physiology and pathophysiology. Cellular and Molecular Life Sciences, 66, 3337-3352. doi:10.1007/s00018-009-0093-4
Topic 3: Regulation of GPCR function by other membrane proteins
- Rozenfeld, R., and Devi, L.A. (2010). Receptor heteromerization and drug discovery. Trends in Pharmacological Sciences, 31, 124-130. doi:10.1016/j.tips.2009.11.008
- Chandrashekar, J., Hoon, M.A., Ryba, N.J.P., Zuker, C.S. (2006). The receptors and cells for mammalian taste. Nature, 444, 288-294. doi:10.1038/nature05401
- Achour, L., Labbé-Jullié, C., Scott, M.G.H., and Marullo, S. (2008). An escort for GPCRs: implications for regulation of receptor density and the cell surface. Trends in Pharmacological Sciences, 29, 528-535. doi:10.1016/j.tips.2008.07.009
- Hay, D.L., Poyner, D.R., and Sexton, P.M. (2006). GPCR modulation by RAMPs. Pharmacology and Therapeutics, 109, 173-197. doi:10.1016/j.pharmthera.2005.06.015
Topic 4: Regulation of GPCR function by intracellular proteins
- Ritter, S.L., and and Hall, R.A. (2010). Fine-tuning of GPCR activity by receptor-interacting proteins. Nature Reviews Molecular Cell Biology, 10, 819-830. doi:10.1038/nrm2803
- Rajagopal, S., Rajagopal, K., and Lefkowitz, R.J. (2010). Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nature Reviews Drug Discovery, 9, 373-386. doi:10.1038/nrd3024
Topic 5: GPCR function; compartmentalisation and integration of signals
- Ahrén, B. (2009). Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes, Nature Reviews Drug Discovery, 8, 369-385, 2009 doi:10.1038/nrd2782
- Lohse, M.J., Nikolaev, V.O., Hein, P., Hoffman, C., Vilardaga, J-P., and Bunemann, M. (2008). Optical techniques to analyze real-time activation and signalling of G-protein-coupled receptors, Trends in Pharmacological Sciences, 29, 159-165. doi:10.1016/j.tips.2007.12.002
- Allen, J.A., Halverson-Tamboli, R.A, and Rasenick, M.A. (2007). Lipid raft microdomains and neurotransmitter signalling. Nature Reviews Neuroscience, 8, 128-140. doi: 10.1038/nrn2059
Dr John Taylor
- Lecture 1 : Overview of Cell Biology 1 : Intracellular Transport
- Lecture 3 : Experimental tools - phenotype screens, gene expression arrays, PCR, transgenics; protein interactions, protein purification and structure determination. cDNA sequences, genomes and protein sequences available from the NCBI web site
- Lecture 6 : How does intracellular vesicular traffic work? What controls targeting? SNAREs and rab proteins.
- Rothman, J., & Orci, L. (1996). Budding vesicles in living cells. Scientific American, 274(3), 70-75.
- Rothman, J., & Solner, T. (1997). Throttles and dampers: Controlling the engine of membrane fusion. Science, 276, 1212-1213.
- Lecture 7 : The Nucleus and Nuclear Transport
Associate Professsor Nigel Birch
Topic 1: Posttranslational modification of biologically active peptides
- Mains, R.E., Dickerson, I.M., May, V., Stoffers, D.A., Perkins, S.N., Ouafik, L., et al. (1990). Cellular and molecular aspects of peptide hormone biosynthesis. Frontiers in Neuroendocrinology, 11, 52-89.
- Halban, P.A., & Irminger, J.C. (1994). Sorting and processing of secretory proteins. Biochemical Journal, 299, 1-18.
- Nakayama, K. (1997). Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins. Biochemical Journal, 327(3), 625-635.
- Seidah, N.G., & Chretien, M. (1999). Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive peptides. Brain Research, 848(1-2), 45-62.
- Zhou, A., Webb, G., Zhu, X., & Steiner, D.F. (1999). Proteolytic processing in the secretory pathway. Journal of Biological Chemistry, 274(30), 20745 - 20748.
- Goodge, K.A., & Hutton, J.C. (2000). Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic B cell. Seminars in Cell & Developmental Biology, 11(4), 235-243.
- Orci, L., Ravazzola, M., Amherdt, M., Madsen, O., Perrelet, A., Vassalli, J.D., et al. (1986). Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles. Journal of Cell Biology, 103(6), 2273-2281.
- Furuta, M., Yano, H., Zhou, A., Rouillé, Y., Holst, J.J., Carroll, R., et al. (1997). Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. Proceedings of the National Academy of Sciences of the United States of America, 94(13), 6646-6651.
- Canaff, L., Bennett, H.P.J., & Hendy, G.N. (1999). Peptide hormone precursor processing: getting sorted? Molecular and Cellular Endocrinology, 156, 1-6.
- Mbikay, M., Seidah, N.G., & Chrétien, M. (2001). Neuroendocrine secretory protein 7B2: structure, expression and functions. Biochemical Journal, 357(2), 329-342.
Topic 2: Targeting of hormones and neuropeptides to the regulated secretory pathway
- Arvan, P., & Castle, D. (1998). Sorting and storage during secretory granule biogenesis: looking backward and looking forward. Biochemical Journal, 332, 593-610.
- Halban, P.A., & Irminger, J.C. (1994). Sorting and processing of secretory proteins. Biochemical Journal, 299, 1-18.
- Molinete, M., Irminger, J., Tooze, S.A., & Halban, P.A. (2000). Trafficking/sorting and granule biogenesis in the B cell. Seminars in Cell and Developmental Biology, 11, 243-251.
- Thiele, C., & Huttner, W.B. (1998). Protein and lipid sorting from the trans-Golgi network to secretory granules - recent developments. Seminars in Cell and Developmental Biology, 9(5), 511 - 516.
- Arvan, P. and Halban, P.A. (2004). Sorting ourselves out: Seeking Consensus on Trafficking in the Beta-Cell. Traffic, 5(1), 53-61.
- Dikeakos, J.D. and Reudelhuber, T.L. (2007).
Sending proteins
to dense core secretory granules: still a lot to sort out. The
Journal of Cell Biology 177 (2), 191-196
Topic 3: Biosynthesis and targeting defects; a new group of (neuro)endocrine diseases
- Leibel, R.L. (1997). And finally, genes for human obesity. Nature Genetics, 16, 218-220.
- Jackson, R.S., Creemers, J.W.M., Ohagi, S., Raffin-Sanson, M., Sanders, L., Montague, C.T. et al. (1997). Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase I gene. Nature Genetics, 16, 303-306
- Rhodes, C.J., & Alarcon, C. (1994). What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism. Diabetes, 43(4), 511-517. (Scroll down to the bottom of the page and click on Acrobat Reader — Full Text — to view and print this article in PDF format.)
- Dhanvantari, S., Shen, F., Adams, T., Snell, C.R., Zhang, C., Mackin, R.B., et al. (2003). Disruption of a receptor-mediated mechanism for intracellular sorting of proinsulin in familial hyperproinsulinemia. Molecular Endocrinology, 17(9), 1856-1867.
Topic 4: Protein misfolding and neurodegeneration
- Selkoe, D.J. (2003). Folding proteins in fatal ways. Nature, 426, 900-904.
- Buxbaum, J.N. (2003). Diseases of protein conformation: what do in vitro experiments tell us about in vivo diseases? Trends in Biochemical Sciences, 28(11), 585-592.
- Ciechanover, A., & Brundin, P. (2003). The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg. Neuron, 40(2), 427-446.
- Haglund, K, & Dakik,
I. (2005). Ubiquitylation
and cell signalling.
EMBO Journal 24 (19), 3353-3359.
- Kerscher, O., Felberbaum,
R. & Hochstrasser, M. (2006). Modification
of Proteins by Ubiquitin and Ubiquitin-like proteins. Annual
Review of Cell and Developmental Biology 22, 159-180.
-
Ciechanover, A. and Ben-Saadon, R. (2004). N-terminal
ubiquitination: more protein substrates join in. Trends
in Cell Biology 14 (3), 103-106.
- Ross, C.A. and Pickart, C.M. (2004). The
ubiquitin-proteasome pathway in Parkinson’s disease and other
neurodegenerative diseases. Trends in Cell Biology 14 (12),
703-711.
- Wilkinson,
K.D., Ventii, K.H., Friedrich, K.L. and Mullally, J.E. (2005). The
ubiquitin signal: assembly, recognition and termination. EMBO
Reports 6, 815-820. (go to 'Archive' on the left hand
column and to the relevant volume/journal)
-
Scheschonka, A., Tang, Z., and
Betz, H. (2007).
Sumoylation in neurons: nuclear and synaptic roles? TRENDS in
Neurosciences 30 (3), 85-91.
Associate Professor David Christie
Topic 1: Membrane Transporters: proteins that move small molecules in and out of cells
Topic 2: The E.coli lactose permease: from purification to three-dimensional structure
- Frillingos, S., Sahin-tótha, M., Wua, J., & Kabacka, H.R. (1998). Cys-scanning mutagenesis: a novel approach to structure-function relationships in polytopic membrane proteins. FASEB Journal, 12(13), 1281-1299.
- Abramson, J., Smirnova, I., Kasho, V., Verner, G., Kaback, H.R. & Iwata, S. (2003). Structure and Mechanism of the Lactose Permease of Escherichia coli. Science, 301(5633), 610-615. [Supporting Online Material]
- Abramson, J., Smirnova, I., Kasho, V., Verner, G., Kaback, H.R. & Iwata, S. (2003) The lactose permease of Escherichia coli: overall structure, the sugar binding site and alternating access model for transport. FEBS Letters, 555(1), 96-101.
Topic 3: Glucose Transporters: Facilitative and Na+-dependent transporters are required to move glucose in and out of mammalian cells
- Simpson, F., Whitehead, J.P., & James, D.E. (2001). Glut4-at the cross roads between membrane trafficking and signal transduction. Traffic, 2(1), 2-11.
- Hediger, M.A. (1994). Structure, function and evolution of solute transporters in prokaryotes and eukaryotes. Journal of Experimental Biology, 196, 15-49.
- Pantaleon, M., Harvey, M.B., Pascoe, W.S., James, D.E., & Kaye, P.L. (1997). Glucose transporter GLUT3: Ontogeny, targeting and role in the mouse blastocyst. Proceedings of the National Academy of Sciences of the United States of America, 94(8), 3795-3800.
Topic 4: ABC Transporters: A family of transporters that contain ATP binding cassette domains
Topic 5: Neurotransmitter Transporters: Three families of transporters involved in neurotransmitter and nutrient uptake
- Nelson, N. (1998), The family of Na+/Cl- Neurotransmitter transporters. Journal of Neurochemistry, 71, 1785-1803.
- Liu, Y., Krantz, D.E., Waites, C., & Edwards, R.H. (1999). Membrane trafficking of neurotransmitter transporters in the regulation of synaptic transmission. Trends in Cell Biology, 9(9), 356-363.
- Giros, B., Jaber, M., Jones, S.R., Wightman, R.M., & Caron, M.G. (1996). Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature, 379(6566), 606-612.
- Xu, F., Gainetdinov, R.R., Wetsel, W.C., Jones, S.R., Bohn, L.M. & Miller, G.Q., et al. (2000). Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nature Neuroscience, 3(5), 465-471.
- Salomons, G.S., van Dooren, S.J.M., Verhoeven, N.M., Cecil, K.M., Ball, W.S., Degrauw, T.J., et al. (2001). X-linked creatine transporter gene (SLC6A8) Defect: A new creatine deficiency syndrome. American Journal of Human Genetics, 68(6), 1497-1500
- Hahn, K.A., Salomons, G.S., Tackels-Horne, D., Wood, T.C., Taylor, H.A., Schroer, R.J., et al. (2002). X-linked mental retardation with seizures and carrier manifestations is caused by a mutation in the creatine-transporter gene (SLC6A8) located in Xq28. American Journal of Human Genetics, 70(5), 1349-1356.
- Rosenberg, E.H., Almeida, L.S., Kleefstra, T., deGrauw, R.S., Yntema, H.G., Bahi, N., et al. (2004). High prevalence of SLC6A8 deficiency in X-linked mental retardation. American Journal of Human Genetics, 75(1), 97-105.
Essay Assignment Help / Conducting Research Using Library Resources
In this course you will have to conduct research using Library databases, electronic journals and print journals to find peer reviewed primary journal articles - this is called a Literature Search. A lecture will be offered for all 353 students to help with the Essay Assignment.
- Essay topics are pre-assigned and each topic will be introduced in the first two weeks of lectures, with an accompanying article to get you started.
- This assignment requires you to conduct research using Library databases, electronic journals and print journals to find peer reviewed primary journal articles relevant to your essay topic - this is called a Literature Search. Primary, Review and Popular Journals, what are the differences?
| It is important to note that you cannot use web sites as information sources for this essay |
When:
The Biological Science Librarian will give an BIOSCI 353 Essay Assignment Lecture on August 3rd, 2010 from 9-10am as an introduction to using library resources for your assignment. Attendance is highly recommended, especially if you have not attended similar presentations in the past.
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Signup for other tutorials:
There will be other tutorials offered during term time, including use of the Scopus database as well as Endnote for Science (although the latter course will mainly be of interest/use to post-graduates).
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Attendance at the following general courses offered by the library is recommended for students new to the University of Auckland, preferably BEFORE attendance at the Essay Assignment presentation for BIOSCI 353 students:
Can't make the Essay Assignment lecture for BIOSCI 353?
- Refer to InfoQuest: the Online Guide to Finding Journal Articles
- Make an appointment with John Lavas, Biological Sciences Subject Librarian for individual assistance.
Attend the general Database Search Skills course offered by the library.
The library runs free courses to help you get the most out of the library resources.
- Another course you should consider doing is Scopus (see details below under Relevant Databases for the Essay Assignment). Scopus tutorials are run by the Biological Science librarian throughout the year, and this database (which includes the information indexed by Medline and several other large databases) will also be of help with other papers you may take in Biology or Biomedical Sciences.
Essay Topic Readings
Will be announced to the class
Relevant Databases for the Essay Assignment
Scopus | User Guide
Scopus is a multi-disciplinary and very powerful science database
that includes over 27 million items from 15 000 peer-reviewed
titles. It also contains information on almost 13 million patents.
Most of its citations link to full text either on Science Direct or
other full-text sources. Scopus includes the same content that
Medline has, although it does not have the online thesaurus of
Medline terms. It is particularly good for author searching and for
citation tracking.
MedLine / PubMed | User Guide
Produced by the U.S. National Library of Medicine, the Medline database is widely recognized as the premier source for bibliographic coverage of biomedical literature. Medline encompasses information from Index Medicus, Index to Dental Literature, and International Nursing Index, as well as other sources of coverage in the areas of communication disorders, population biology, and reproductive biology. More than 11 million records from more than 4,600 journals are indexed and abstracted. Medline uses OVID software.
PubMed is the free version of MedLine that exists on the web and covers the exact same material as MedLine. The advantage of using MedLine over PubMed is that MedLine has been customised for the University of Auckland and links through to all available electronic journals. As PubMed is a free database on the Internet customisation for the University of Auckland is not possible.
Biological Abstracts | User Guide
Biological Abstracts is an international database on biology, clinical and experimental medicine, biochemistry and biotechnology. It indexes and abstracts articles in 6,500 serials from over 100 countries and is produced in the United States by BIOSIS.
Web of Science | User Guide
Also known as the Science Citation Index, The Web of Science is a mutlidisciplinary database listing 20 million items from over 8000 journals. Most items are in the Sciences, but it is also useful for the Social Sciences, Arts & Humanities.
Complete listing of all Biological Sciences Databases
Electronic Resources
Cell Biology Electronic Journals: (a small selection)
- Dates after journal titles indicate which volumes are available electronically, if you require articles from earlier dates check Voyager for availability of print versions of these journals.
- Primary, Review and Popular Journals, what are the differences?
- To access these electronic resources refer to the Accessing Electronic Resources : On Campus | From Home instructions.
Review Journals
Other Journals
Online Reference books
Web Sites (a small selection)
To access these electronic resources refer to the Accessing Electronic Resources : On Campus | From Home instructions.
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